Frequency of oral submucous fibrosis among 100 south indians with oral cancer. The pathogenesis of osf is not well established, al though a. Oral submucous fibrosis causes, symptoms, treatment and. All of these greatly interfere with patient quality of life. Know all about the disease, including its possible causes, symptoms, diagnosis and treatment options. Jul 24, 2018 oral submucous fibrosis osmf etiology epidemiological data and intervention studies suggest that areca nut is the main aetiological factor for osf pindbor. Sep 19, 2017 oral submucous fibrosis and its pathogenesis 1. Background oral submucous fibrosis is a disease due to a chronic, insidious change in fibroelasticity, characterized by burning sensation in the. In fibrotic connective tissue lesions without marked inflammation such as osmf, the main route of collagen degradation is by phagocytosis and. Review on aetiology and pathogenesis author links open overlay panel w. It is characterized by a generalized submucosal fibrosis. The symptoms and signs depend on the progression of the lesions and number of affected sites. Pathogenesis of oral submucous fibrosis semantic scholar.
Nov 24, 2012 oral submucous fibrosis osf is an extremely discomforting oral condition that is marked by the development of painful lesions inside the mouth that refuse to go away on their own. Lysyl oxidase gene loxg473a expression in pathogenesis and malignant transformation of oral submucous fibrosis e859 introduction oral submucous fibrosis is a chronic debilitating disease and a potentially malignant condition of oral cavity. Oral submucous fibrosis osf is a premalignant condition mainly associated with the practice of chewing betel quid containing areca nut, a habit common among south asian people. Oral submucous fibrosis 31 in europe or north america. Introduction history definition epidemiology nomenclature classification etiopathogenesis clinical features histopathology differential diagnosis special investigations malignant potential treatment and management.
Oral submucous fibrosis osf is a chronic debilitating disease and a premalignant condition of the oral cavity. The available epidemiological data showed a clearcut geographical and ethnic predisposition, which suggested that certain. Over the last 40 years, many theories linking oral submucous fibrosis osmf to various risk factors have been proposed. Various theories have been put forth since many decades by many researchers about the pathogenesis of oral submucous fibrosis.
Pathogenesis and therapeutic intervention of oral submucous. Involvement in the pathogenesis of oral submucous fibrosis chengchia yu1,2,3, chunghung tsai4,5, hsini hsu1, yuchao chang2,3. It is a chronic progressive disorder and its clinical features depend on the stage of the. A possible role in pathogenesis of oral submucous fibrosis. Osmf is characterized by deposition of dense collagen. Circulating autoantibodies are also present in some cases of oral submucous fibrosis canniff et al, 1985. It is characterized by inflammation, increased deposition of submucosal collagen and formation of fibrotic bands in the oral and paraoral tissues, which increasingly limit. Comparison of mouth opening with different nonsurgical treatment modalities in oral submucous fibrosis karthik p.
Mechanism of pathogenesis introduction oral submucous fibrosis, first described in the early1950s, is a potentially malignant disease predominantly seen in people of asian descent. Oral submucous fibrosis osf is a premalignant condition mainly associated with the practice of. In addition research in some aspects of carcinogenesis in the background of fibrosis has also advanced significantly in the recent past allowing us to understand the. Comparison of mouth opening with different nonsurgical. Although occasionally preceded andor associated with vesicle formation, is always associated with. Oral submucous fibrosis osf is a potentially malignant disorder carrying the highest risk of malignant transformation among the oral premalignant lesions. These raised levels suggest an antigenic stimulus in the absence of any infection. Role of microrna profiling in oral submucous fibrosis.
Etiopathogenesis and management of oral submucous fibrosis. It is well recognised as potentially malignant disorder which is associated mainly with the use of arecanut in various forms. The pathogenesis of osmf involves disruption of collagen metabolism by components of areca nut. It is a precancerous disorder and transforms into a malignant tumor in 1. Oral submucous fibrosis can be seen at any age except for young children. Elevation of s100a4 expression in buccal mucosal fibroblasts. Nov 14, 2015 one such reaction of the collagen of oral mucosa to arecanut is oral submucous fibrosis. Oral submucous fibrosis results from increased production of collagen by fibroblasts.
Oral submucous fibrosis osf is a premalignant disorder associated with the chewing of areca nut betel nut. Oral submucous fibrosis osf is characterized by abnormal collagen deposition. O ral submucous fibrosis is a chronic, insidious disease affecting the oral cavity and sometimes pharynx. Elevation of s100a4 expression in buccal mucosal fibroblasts by arecoline. Oral submucous fibrosis osf is a premalignant condition caused by betel chewing. Oral submucous fibrosis osf is a chronic, progressive, potentially malignant condition affecting the oral cavity and frequently involving the upper part of the aerodigestive tract including the oropharynx and the upper part of the esophagus. Oral submucous fibrosis a study 1yousuf a lakdawala 2rida arshad 3syeda maria fakhar abstract oral submucous fibrosis osmf is a debilitating precancerous condition of oral mucosa characterized by the fibrosis of oral mucosa, burning sensation in mouth, intolerance to spicy food and progression of the disease leading to limitation of mouth. Oral submucous fibrosis is considered to be a potentially malignant disease caused primarily due to areca nut chewing. Oral submucous fibrosis oral surgery, oral medicine, oral. Comparative evaluation of role of lysyl oxidase gene.
Spicy, pungent foods and irritants such as supari areca nut, paan betel leaves, tobacco through chewing or smokingthe common asian habits of chewing the aforementioned agentshave all been incriminated as causative agents. It is characterised by inflammation and progressive fibrosis of the submucosal tissue. Molecular pathogenesis of oral submucous fibrosis a collagen metabolic disorder. Spicy, pungent foods and irritants such as supari areca nut, paan betel lea. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. Oral submucous fibrosis is a disease due to a chronic, insidious change in fibroelasticity, characterized by burning sensation in the oral cavity, blanching, and stiffening of the oral mucosa and oropharynx leading to trismus and inability to open the mouth. Areca nut in pathogenesis of oral submucous fibrosis. Treatment etiopathogenesis and management of oral submucous fibrosis seema basoya department of oral medicine and radiology, s. The disease is rare in north america, and most cases seen in. Betel nut and pan are freely available in the united kingdom, and in a city such as leicester, one might expect to find 3000 cases of oral submucosal fibrosis. The pathogenesis of the disease is not well established.
Oral submucous fibrosis osf is a chronic disease of the oral mucosa characterized by inflammation and a progressive fibrosis of the lamina propria and deeper connective tissues. Compared to traditional betel quid, gutkha chewing tends to begin at a younger age and has a shorter time to the development of disease, so cases of oral submucous fibrosis have been seen as young as 11 years of age. Pdf pathogenesis of oral submucous fibrosis researchgate. Oral submucous fibrosis osmf is a chronic disease of insidious onset and a prevailing potentially malignant disorder characterized by juxtaepithelial inflammatory reaction along with mucosal fibrosis. The habit is prevalent in south asian populations but has been recognized nowadays also in europe and north america. Pdf pathogenesis and therapeutic intervention of oral. It is a condition predominantly seen among people of indian origin, and an epidemiologic survey done a decade ago showed no less than 250,000 cases in india, a figure. Review article pathogenesis of oral submucous fibrosis. Pathogenesis of oral submucous fibrosis khan s, chatra l. Oral submucous fibrosis osmf, a precancerous condition of the oral cavity, has been studied by a number of workers in the field. Oral submucous fibrosis, a clinically benign but potentially. The available epidemiological data showed a clearcut geographical and ethnic predisposition, which suggested that certain customshabits prevalent among the population groups in southeast asia might be possible etiological factors. Oral submucous fibrosis current concepts in etiopathogenesis.
Molecular pathogenesis of oral submucous fibrosis a. It is very common in southeast asia but has started to spread to europe and north america. Oral submucous fibrosis osmf is a chronic disease of oral mucosa characterized by inflammation and progressive fibrosis followed by stiffening of an otherwise yielding mucosa resulting in difficulty in opening the. Epidemiological evidences strongly indicate the association of the betel quid bq habit and osf. The incidence of oral squamous cell carcinoma has been estimated to be 7. Molecular pathogenesis of oral submucous fibrosisa collagen metabolic disorder. Oral submucous fibrosis osf is a chronic, progressive, potentially malignant condition of the oral cavity, which has the highest malignant transformation potential of 7%. Molecular pathogenesis of oral submucous fibrosis wiley online. Further, the understanding of mechanisms of malignant transformation may lead to early diagnosis of oral squamous cell carcinoma oscc. Oral submucous fibrosis osf is the chronic debilitating and crippling condition of oral mucosa. A wide range of treatment modalities have been proposed for osf, but none have proved curative or reduced the morbidity significantly.
Molecular pathogenesis of oral submucous fibrosisa collagen. Dental college, hospital and research institute, india introduction oral submucous fibrosis was first described by schwartz in 1952 among five indian females living in kenya and he coined. Oral submucous fibrosis osmf etiology epidemiological data and intervention studies suggest that areca nut is the main aetiological factor for osf pindbor. The upregulation of cyclooxygenase2 expression in human buccal mucosal fibroblasts by arecoline.
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